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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
2000 1
2001 3
2003 5
2004 10
2005 5
2006 8
2007 3
2008 6
2009 10
2010 10
2011 12
2012 8
2013 16
2014 14
2015 9
2016 10
2017 12
2018 15
2019 23
2020 8
2021 16
2022 13
2023 5
2024 4

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192 results

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Page 1
Metformin, Macrophage Dysfunction and Atherosclerosis.
Feng X, Chen W, Ni X, Little PJ, Xu S, Tang L, Weng J. Feng X, et al. Front Immunol. 2021 Jun 7;12:682853. doi: 10.3389/fimmu.2021.682853. eCollection 2021. Front Immunol. 2021. PMID: 34163481 Free PMC article. Review.
More and more evidence shows that metformin can regulate the function of macrophages in atherosclerosis, including reducing the differentiation of monocytes and inhibiting the inflammation, oxidative stress, polarization, foam cell formation and apoptosis of macrophages. . …
More and more evidence shows that metformin can regulate the function of macrophages in atherosclerosis, including reducing the diffe …
ABCG5/ABCG8 in cholesterol excretion and atherosclerosis.
Yu XH, Qian K, Jiang N, Zheng XL, Cayabyab FS, Tang CK. Yu XH, et al. Clin Chim Acta. 2014 Jan 20;428:82-8. doi: 10.1016/j.cca.2013.11.010. Epub 2013 Nov 16. Clin Chim Acta. 2014. PMID: 24252657 Review.
Consistent with their function, ABCG5 and ABCG8 are located on the apical membrane of enterocytes and hepatocytes. ...Overexpression of ABCG5 and ABCG8 in mice retards diet-induced atherosclerosis because of reduced circulating and hepatic cholesterol. ...
Consistent with their function, ABCG5 and ABCG8 are located on the apical membrane of enterocytes and hepatocytes. ...Overexpression …
Update on Sitosterolemia and Atherosclerosis.
Rocha VZ, Tada MT, Chacra APM, Miname MH, Mizuta MH. Rocha VZ, et al. Curr Atheroscler Rep. 2023 May;25(5):181-187. doi: 10.1007/s11883-023-01092-4. Epub 2023 Mar 10. Curr Atheroscler Rep. 2023. PMID: 36897412 Review.
This sterol storage condition is caused by biallelic loss-of-function genetic variants in either ABCG5 or ABCG8, leading to increased intestinal absorption and decreased hepatic excretion of plant sterols. ...Indeed, recent studies have suggested that genetic variants in …
This sterol storage condition is caused by biallelic loss-of-function genetic variants in either ABCG5 or ABCG8, leading to increased …
ABCG5 and ABCG8: more than a defense against xenosterols.
Patel SB, Graf GA, Temel RE. Patel SB, et al. J Lipid Res. 2018 Jul;59(7):1103-1113. doi: 10.1194/jlr.R084244. Epub 2018 May 4. J Lipid Res. 2018. PMID: 29728459 Free PMC article. Review.
ABCG5/ABCG8 are key in regulating whole-body sterol trafficking, by eliminating sterols via the biliary tree as well as the intestinal tract. ...While polymorphic variants raise or lower the risks of these phenotypes, loss of function of this locus leads to more dramatic p …
ABCG5/ABCG8 are key in regulating whole-body sterol trafficking, by eliminating sterols via the biliary tree as well as the intestina …
Phytosterols and Cardiovascular Disease.
Makhmudova U, Schulze PC, Lütjohann D, Weingärtner O. Makhmudova U, et al. Curr Atheroscler Rep. 2021 Sep 1;23(11):68. doi: 10.1007/s11883-021-00964-x. Curr Atheroscler Rep. 2021. PMID: 34468867 Free PMC article. Review.
Recent advances in ABCG5 and ABCG8 variants.
Fong V, Patel SB. Fong V, et al. Curr Opin Lipidol. 2021 Apr 1;32(2):117-122. doi: 10.1097/MOL.0000000000000734. Curr Opin Lipidol. 2021. PMID: 33395105 Free PMC article. Review.
PURPOSE OF REVIEW: In this review, we summarize the genetics and mechanisms of sitosterolemia and sterol trafficking, and provide an update on the understanding of the prevalence of ABCG5 and ABCG8 variants and their role in human disease. RECENT FINDINGS: Defects in AB …
PURPOSE OF REVIEW: In this review, we summarize the genetics and mechanisms of sitosterolemia and sterol trafficking, and provide an update …
Plant sterols and atherosclerosis.
Silbernagel G, Genser B, Nestel P, März W. Silbernagel G, et al. Curr Opin Lipidol. 2013 Feb;24(1):12-7. doi: 10.1097/MOL.0b013e32835b6271. Curr Opin Lipidol. 2013. PMID: 23165086 Review.
However, these data do not prove a causal role for plant sterols in atherosclerosis because the risk alleles in ABCG8 and ABO are also related to elevated total and LDL cholesterol levels. ...
However, these data do not prove a causal role for plant sterols in atherosclerosis because the risk alleles in ABCG8 and ABO are als …
Atherosclerosis, diabetes and lipoproteins.
Tomkin GH. Tomkin GH. Expert Rev Cardiovasc Ther. 2010 Jul;8(7):1015-29. doi: 10.1586/erc.10.45. Expert Rev Cardiovasc Ther. 2010. PMID: 20602562 Review.
The enormous burden of vascular disease is likely to expand rapidly as sedentary obesity and diabetes increase. Although cholesterol plays a major role in atherosclerosis and LDL is the major carrier of cholesterol in the blood, the importance of the postprandial triglycer …
The enormous burden of vascular disease is likely to expand rapidly as sedentary obesity and diabetes increase. Although cholesterol plays a …
Association of ABCG5 and ABCG8 Transporters with Sitosterolemia.
Bydlowski SP, Levy D. Bydlowski SP, et al. Adv Exp Med Biol. 2024;1440:31-42. doi: 10.1007/978-3-031-43883-7_2. Adv Exp Med Biol. 2024. PMID: 38036873 Review.
ABCG5/G8 encodes a pair of ABC half transporters that form a heterodimer (G5G8). ...Here, we review the biological characteristics and function of ABCG5/G8, and how the mutations of ABCG5/G8 can cause sitosterolemia, a loss-of-function disorder characterized …
ABCG5/G8 encodes a pair of ABC half transporters that form a heterodimer (G5G8). ...Here, we review the biological characteristics an …
Atherosclerosis: lessons from LXR and the intestine.
Bonamassa B, Moschetta A. Bonamassa B, et al. Trends Endocrinol Metab. 2013 Mar;24(3):120-8. doi: 10.1016/j.tem.2012.10.004. Epub 2012 Nov 15. Trends Endocrinol Metab. 2013. PMID: 23158108 Review.
Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in atherosclerosis. The intestine is important for its unique capabilities to act as a gatekeeper for cholesterol absorption and to part …
Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in …
192 results